"Transdermal Telmisartan Patch Development With Natural Permeation Enhancers: Ex Vivo Release Comparison"

Abstract

The aim of this research was to develop and evaluate matrix-type transdermal patches containing Telmisartan using various polymers and to investigate the impact of Cumin seed extract on the bioavailability of Telmisartan. We conducted Fourier Transform Infrared (FTIR) Spectroscopy analysis to examine the physicochemical compatibility between the drug and the polymers. Our findings indicated that there were no significant physicochemical differences between the drug and the polymers. To assess the quality of the formulated transdermal patches, we conducted various tests, including weight variation, thickness, folding endurance, moisture loss, moisture absorption, ex-vivo drug release, and ex-vivo drug absorption. For the best formulation, F41, we observed the following characteristics: a thickness of 0.298±0.012mm, weight uniformity of 0.291±0.021gm, moisture uptake of 7.434±2.435%, moisture content of 8.341±0.671%, drug content of 80.32±0.619%, and folding endurance of 29±3.61. Notably, formulation F41 exhibited the highest cumulative drug release of 68.25±1.14% within 8 hours and the highest drug absorption rate of 2.994±0.73% within 120 minutes.